• Skip to primary navigation
  • Skip to main content
  • Skip to primary sidebar
  • Skip to footer

Johns Hopkins Medicine Lyme Disease Research Center

Show Search
Hide Search
  • Lyme Disease
    • Signs & Symptoms of Lyme Disease
    • Diagnosis of Lyme Disease
    • Lyme Disease Treatment and Prognosis
    • Lyme Disease Prevention, Tick Removal, & Health and Wellness Tips
    • Frequently Asked Questions (FAQs)
    • Lyme Disease Video Introduction Series
    • Lyme Disease Video Education Resources
  • About the Center
    • Meet Our Team
    • Make an Appointment
    • Address & Directions
    • Refill a Prescription
    • Lyme and Tickborne Disease Fellowship Program
    • Subscribe to Our Email Newsletter
  • News & Impact
    • Impact Report
    • Newsletters
    • Research News
    • In The News
    • Talks by John Aucott, MD
    • Subscribe to Our Email Newsletter
  • Research Studies
    • Open Research Studies
    • Clinical Trials Network for Lyme and Other Tick-Borne Diseases
    • Research Publications
    • Lyme Disease Epidemiology
  • Make a Gift
  • Newsletter Signup
Home / Lyme Disease Video Education Resources / How to Distinguish the Signs & Symptoms of Acute Lyme Disease from COVID-19?

How to Distinguish the Signs & Symptoms of Acute Lyme Disease from COVID-19?

May 7, 2020 By Johns Hopkins Lyme Disease Research Center

Although many of the early “flu-like” symptoms of COVID-19 and Lyme disease are similar, there are important differences that can help distinguish between these infections.

Similar Flu-Like Symptoms:

  • Fever
  • Chills
  • Body/muscle aches and pains
  • Fatigue
  • Malaise
  • Sweats
  • Headache

Differences

Signs and symptoms present in Lyme Disease but not typical in COVID-19:

  • Large expanding red round rash
  • Neck and joint pain

Signs and symptoms present in COVID-19 but not typical in Lyme Disease:

  • Respiratory issues
    • Dry cough
    • Shortness of Breath
    • Pain of pressure in the chest
    • Trouble breathing
  • Loss of taste or smell
  • Digestive issues like vomiting or diarrhea
  • Nasal congestion
  • Bluish lips or face
  • Diffuse rash or “COVID toes” that look similar to frost bite

Not everyone with Lyme Disease or COVID-19 will get a rash but when present a rash can be an important distinguishing feature for aiding early diagnosis.

Lyme Disease Awareness Month Information


Receive the Latest News from the Johns Hopkins Lyme Disease Research Center

Receive the Latest News from the Johns Hopkins Lyme Disease Research Center

Join our mailing list to receive the latest news and updates from Johns Hopkins Rheumatology and the Johns Hopkins Lyme Disease Research Center.

Interested In

You have Successfully Subscribed!

Filed Under: Lyme Disease Awareness, Lyme Disease Video Education Resources Tagged With: Johns Hopkins 2020 Lyme Disease Awareness Campaign

Johns Hopkins Lyme Disease Research Center

Johns Hopkins Lyme Disease Research Center

The Johns Hopkins Lyme Disease Research Center is focused on patient-based research in all manifestations of Lyme disease. Our goal is to translate our pioneering research into improved patient care, education, and health outcomes.

Use of This Site

All information contained within the Johns Hopkins Lyme Disease Research Center website is intended for educational purposes only. Physicians and other health care professionals are encouraged to consult other sources and confirm the information contained within this site. Consumers should never disregard medical advice or delay in seeking it because of something they may have read on this website.

Primary Sidebar

Recent Advances in Lyme Disease Webinar for Patients

Wednesday, May 4, 2022 7-9 PM
Free Webinar via Zoom
Open to the Public
Sponsored by the Lyme Care Resource Center

Register Today

Lyme Disease Symposium for Healthcare Practitioners
Clinical and Research Advances in Lyme Disease

Friday, May 6, 2022 10-4 PM ET
Free Symposium via Zoom
Available to healthcare providers
Sponsored by the Johns Hopkins Lyme Disease Research Center

Register Today

Footer

Johns Hopkins Rheumatology

  • Johns Hopkins Rheumatology
  • Arthritis Center
  • Lupus Center
  • Myositis Center
  • Scleroderma Center
  • Sjögren’s Syndrome Center
  • Vasculitis Center

Connect with Us

  • Facebook
  • Twitter
  • YouTube

U.S. News and World Report Rankings Badge

Johns Hopkins Medicine

© 2025 Johns Hopkins Lyme Disease Research Center
Patient Privacy