Summary This case study describes an African-American male who was misdiagnosed for 7 weeks despite the patient exhibiting common symptoms and signs of Lyme disease (including EM rash and facial […]
This study shows that the General Symptom Questionnaire-30 (GSQ-30) is a valid and reliable self-report instrument that clinicians and researchers could use to assess the multi-system symptom burden and response to treatment among patients with acute and post-treatment Lyme disease.
This pilot study showed a direct molecular Lyme disease diagnostic test could be used to identify and genotype Borrelia burgdorferi during antibiotic treatment in early Lyme disease patients. Findings suggest that the host immune system or differential antibiotic susceptibility might have played a role in the observed genotypic shift.
Recognition of the EM rash is crucial to early diagnosis and treatment. Improved rash recognition using deep learning methodology to prescreen patient rash photos may help prevent later serious manifestations of Lyme disease.
This study uses a neuroimaging radiotracer with positron emission tomography (PET) to quantify cerebral glial activation in brains of patients with post-treatment Lyme disease. Results show elevated central nervous system immune activation in patients with PTLDS as compared to controls.
Lyme disease (Borrelia burgdorferi infection) is increasingly recognized as a significant worldwide illness. This study provides insights into important immune mechanisms involved in Borrelia burgdorferi clearance in human Lyme disease.
